February 1, 1985Journal of Hypertension

Renin Gene Expression in Vessels of the Ovine Renal Cortex

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Population

Ovine (sheep) renal cortex tissue sections

Design

Preclinical

Authors

IDIan A. DarbyRMIT University PAP. AldredFlorey Institute of Neuroscience and Mental Health RCRobert J. CrawfordINSEAD

Discussion

Member takes

Implication

Hypothesis-generating for renin sites in sheep kidney; leaves open human relevance and requires validation before any clinical consideration.

Structured PICO

Population

Ovine (sheep) renal cortex tissue sections

Intervention

Hybridization histochemistry using a 700 base pair recombinant DNA probe coding for ovine renin

Outcome

Localization of renin gene expressionsurrogate

This study provides morphological evidence that renin is synthesized and stored in the afferent arteriole and the smooth muscle coat of interlobular arteries in the sheep kidney.

Cite This Study

Darby et al. (1985) studied this question.

synapsesocial.com/papers/6a8bd53e77493d51bfdeed87 https://doi.org/10.1097/00004872-198502000-00002

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Implication

Hypothesis-generating for renin sites in sheep kidney; leaves open human relevance and requires validation before any clinical consideration.

Renin Gene Expression in Vessels of the Ovine Renal Cortex

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Renin Gene Expression in Vessels of the Ovine Renal Cortex

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider