Why the study?
Does enalapril alter lung structure and surface tension in neonatal rats?
Does enalapril alter lung structure and surface tension in neonatal rats?
Early postnatal ACE inhibition with enalapril in rats interferes with normal lung development, causing structural and functional alterations.
Neonatal ACE inhibition may disrupt lung development in rats; leaves open human relevance and requires further study before clinical consideration.
The renin-angiotensin system (RAS) is developmentally up-regulated and it is essential for kidney development in several species. Given the fact that the rat lung undergoes postnatal development, the mammalian lung possesses the highest angiotensin-converting enzyme (ACE) levels and ACE activity increases during the first weeks postpartum, we tested the hypothesis that ACE inhibition influences postnatal lung development. Rats were given the ACE inhibitor enalapril (10 mg kg(-1)) from 0 to 9 days of age and their lungs were examined at day 4 and 9. Lung structure was evaluated by means of light microscopy, and surface tension of bronchoalveolar lavage fluid was measured by means of a Wilhelmy balance. Neonatal ACE inhibition lowered the surface tension of bronchoalveolar lavage fluid and caused widening of respiratory airspaces and thinning of alveolar septa. Our results suggest that early postnatal ACE inhibition in rats interferes with lung development.
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Lasaitiene et al. (2004) studied this question.
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