Why the study?
Is serum angiotensin converting enzyme (ACE) activity elevated in patients with chronic renal failure on regular hemodialysis compared to age-matched controls?
Is serum angiotensin converting enzyme (ACE) activity elevated in patients with chronic renal failure on regular hemodialysis compared to age-matched controls?
Serum ACE activity is significantly elevated in patients with chronic renal failure on hemodialysis, which may reflect diffuse vascular damage.
ACE elevation in long-term HD may mark vascular damage; hypothesis-generating, needs prospective validation before any clinical use.
Serum angiotensin converting enzyme (ACE) activity in patients with chronic renal failure (CRF) on regular hemodialysis (HD) was measured. The enzyme activity of these patients was significantly higher than that of an age-matched control group. Additionally, we found that an elevated activity was observed in patients who had a longer history of HD. The enzyme activity in patients with CRF caused by diabetic nephropathy was higher than that in patients with CRF caused by chronic glomerulonephritis, though this difference was not significant. We conclude that diffuse vascular damage might be the cause of the increased ACE activity seen in CRF.
No takes yet. Share an insight, caveat, or question.
Miura et al. (1984) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: