Why the study?
Does combination therapy of mexiletine and sotalol improve clinical signs in a dog with ventricular premature contractions?
Does combination therapy of mexiletine and sotalol improve clinical signs in a dog with ventricular premature contractions?
Combination therapy with mexiletine and sotalol successfully improved clinical signs in a dog with ventricular premature contractions.
May support mexiletine for canine monomorphic VPCs; hypothesis-generating and leaves open need for controlled trials.
A nine-year-old female Cocker Spaniel dog was presented to the Teaching Veterinary Clinical Complex, Pookode with clinical signs of anorexia, shivering, weakness and exercise intolerance. Dyspnoea and pulse deficit were observed on general clinical examination. Cardiac auscultation revealed arrhythmia. On electrocardiography examination, monomorphic ventricular premature complexes and ST segment coving were observed. The animal was treated with mexiletine tablets at 4 mg per kg body weight and sotalol at 0.5 mg per kg body weight orally. The animal showed marked improvement in clinical signs by one month.
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Daniel et al. (2023) studied this question.
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