Why the study?
To describe the efficacy of oral mexiletine in suppressing ventricular arrhythmias and its safety in dogs.
Does oral mexiletine improve ventricular arrhythmia suppression in dogs when added to first-line therapy?
Population
38 dogs with ventricular arrhythmias ineffectively controlled by initial monotherapy
Comparison
Oral mexiletine added as a second-line antiarrhythmic to a first-line agent
Design
Multicentre retrospective study
Authors
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Supports mexiletine consideration for canine ventricular arrhythmias; hypothesis-generating and requires randomized trials before practice change.
Does oral mexiletine improve ventricular arrhythmia suppression in dogs when added to first-line therapy?
Oral mexiletine is highly effective as a second-line agent for suppressing ventricular arrhythmias in dogs, though reversible gastrointestinal side effects are common.
Romito et al. (2025) studied this question.