Why the study?
Does mexiletine suppress ventricular arrhythmias in canine models?
Population
Canine ventricular arrhythmia models, n=6-7 per group
Design
Preclinical
Authors
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Mexiletine suppresses canine ventricular arrhythmias; leaves open human translation and dosing.
Does mexiletine suppress ventricular arrhythmias in canine models?
Mexiletine effectively suppresses various canine ventricular arrhythmias, with the minimum effective plasma concentration being highest for adrenaline-induced arrhythmias.
Hashimoto et al. (1984) studied this question.
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