What does this research mean for the field?

Intravenous mexiletine significantly prolongs atrio-ventricular conduction distal to the bundle of His, but does not significantly affect sinus node recovery time or other refractory periods in the intact human heart. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the electrophysiological effects of intravenous mexiletine on the intact human heart in individuals without cardiovascular disease.

January 1, 1977Scandinavian Journal of Clinical and Laboratory Investigation

The effect of mexiletine on the electrophysical properties of the intact human heart

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Why the study?

Does intravenous mexiletine alter the electrophysiological properties of the heart in subjects without cardiovascular disease?

Population

10 subjects with no evidence of cardiovascular disease

Design

Other

Authors

RHRichard W. HarperMemorial Sloan Kettering Cancer Center SOSigvard OlssonKarolinska University Hospital EVEd VarnauskasUniversity of Gothenburg

Discussion

Member takes

Implication

May warrant caution in conduction disease patients; leaves open effects in diseased hearts.

Key Points

To evaluate the electrophysiological effects of intravenous mexiletine on the intact human heart in individuals without cardiovascular disease.
Administered an intravenous dose of the anti-arrhythmic agent mexiletine to ten subjects (N=10) with no evidence of cardiovascular disease.
Measured sinus node recovery time, effective refractory periods across atrial and ventricular tissues, and proximal versus distal atrioventricular conduction.
Mexiletine produced no significant changes in sinus node recovery time, corrected sinus node recovery time, proximal atrioventricular conduction, or atrial, atrioventricular, and ventricular effective refractory periods.
The drug prolonged atrioventricular conduction distal to the bundle of His by an average of 6 msec in all ten subjects (P < 0.01).

Structured PICO

Does intravenous mexiletine alter the electrophysiological properties of the heart in subjects without cardiovascular disease?

Population

10 subjects with no evidence of cardiovascular disease

Intervention

Intravenous mexiletine

Outcome

Electrophysiological properties of the intact human heart (including sinus node recovery time, refractory periods, and atrioventricular conduction)surrogate

Intravenous mexiletine significantly prolongs distal atrio-ventricular conduction in healthy subjects, highlighting the need for caution in patients with underlying conduction disease.

Cite This Study

Harper et al. (1977) studied this question.

synapsesocial.com/papers/6a158146cb801b7f954e95e2 https://doi.org/10.3109/00365517709101838

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The effect of mexiletine on the electrophysical properties of the intact human heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The effect of mexiletine on the electrophysical properties of the intact human heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider