May 1, 1979Cardiovascular Research

Electrophysiological actions of mexiletine on isolated rabbit atria and canine ventricular muscle and Purkinje fibres

View Full Paper

Ask AI

Bookmark

Why the study?

Does mexiletine alter electrophysiological properties in isolated rabbit and canine cardiac tissues?

Population

Isolated rabbit sinus node and atrial preparations, and canine ventricular muscle and Purkinje fibres

Design

Preclinical

Authors

IYIchiro YamaguchiNational Institute of Public Health BSB. N. SinghAligarh Muslim University WMWilliam J. MandelElectrophysiology

Discussion

Member takes

Implication

Hypothesis-generating in isolated tissues; leaves open clinical relevance for human arrhythmia management.

Structured PICO

Does mexiletine alter electrophysiological properties in isolated rabbit and canine cardiac tissues?

Population

Isolated rabbit sinus node and atrial preparations, and canine ventricular muscle and Purkinje fibres

Intervention

Mexiletine at varying concentrations (0.5 to 2.0 micrograms.cm-3) in oxygenated Tyrode solution at 35 degrees C

Outcome

Electrophysiological effects including action potentials, sinus node automaticity, sino-atrial conduction, dV/dtmax of phase 0, conduction velocity, membrane responsiveness, action potential duration, and effective refractory periodsurrogate

Mexiletine demonstrates complex antiarrhythmic electrophysiological effects in isolated cardiac tissues that resemble those of lidocaine.

Cite This Study

Yamaguchi et al. (1979) studied this question.

synapsesocial.com/papers/6a7d0b1aab1caed3bf748ffd https://doi.org/10.1093/cvr/13.5.288

View Full Paper

Ask AI

Bookmark

Electrophysiological actions of mexiletine on isolated rabbit atria and canine ventricular muscle and Purkinje fibres

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrophysiological actions of mexiletine on isolated rabbit atria and canine ventricular muscle and Purkinje fibres

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider