December 1, 1985British Journal of PharmacologyOpen Access

Electrophysiological mechanisms for the antiarrhythmic action of mexiletine on digitalis‐, reperfusion‐ and reoxygenation‐induced arrhythmias

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Population

Guinea-pig isolated hearts and sheep cardiac Purkinje fibres

Design

Preclinical

Authors

SASandra AmeriniUniversity of Florence PCPierugo CarboninUniversità Cattolica del Sacro Cuore ECElisabetta CerbaiElectrophysiology

Discussion

Member takes

Implication

Mexiletine may suppress triggered activity via afterpotential reduction in animal models; leaves open clinical translation for digitalis- or reperfusion arrhythmias.

Structured PICO

Population

Guinea-pig isolated hearts (3 groups: digitalis intoxication, hypoxia followed by reoxygenation, and ischaemia followed by reperfusion) and sheep cardiac Purkinje fibres (manifesting oscillatory afterpotentials and triggered automaticity induced by barium or strophanthidin)

Intervention

Mexiletine 10 microM

Outcome

Antiarrhythmic potency, amplitude of oscillatory afterpotentials, triggered activity, and Vmaxsurrogate

Mexiletine suppresses arrhythmias induced by digitalis, reperfusion, and reoxygenation by reducing oscillatory afterpotentials and triggered activity in preclinical models.

Cite This Study

Amerini et al. (1985) studied this question.

synapsesocial.com/papers/6a8834fbafcf99b77fbc0005 https://doi.org/10.1111/j.1476-5381.1985.tb11102.x

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Implication

Mexiletine may suppress triggered activity via afterpotential reduction in animal models; leaves open clinical translation for digitalis- or reperfusion arrhythmias.

Electrophysiological mechanisms for the antiarrhythmic action of mexiletine on digitalis‐, reperfusion‐ and reoxygenation‐induced arrhythmias

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrophysiological mechanisms for the antiarrhythmic action of mexiletine on digitalis‐, reperfusion‐ and reoxygenation‐induced arrhythmias

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider