Why the study?
Does mexiletine effectively suppress ventricular arrhythmias in patients with acute myocardial infarction or chronic ventricular ectopy?
Population
Patients with ventricular arrhythmias, including those in the acute phase of myocardial infarction, stable…
Design
Review
Authors
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May warrant consideration for refractory ventricular ectopy; leaves open its role in acute MI without randomized data.
Does mexiletine effectively suppress ventricular arrhythmias in patients with acute myocardial infarction or chronic ventricular ectopy?
Mexiletine is an effective antiarrhythmic agent for ventricular ectopy, comparable to quinidine, procainamide, and disopyramide, though its use is limited by gastrointestinal and central nervous system side effects in approximately 20% of patients.
Fenster et al. (1986) studied this question.
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