Why the study?
Does mexiletine affect ventricular conduction intervals of premature ventricular beats in human subjects?
Population
9 human subjects
Comparison
Mexiletine vs Control recordings (baseline)
Design
Other
Authors
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May influence PVC-related arrhythmia risk; extends class Ib effects on human ventricular conduction intervals.
Does mexiletine affect ventricular conduction intervals of premature ventricular beats in human subjects?
Mexiletine abolishes supernormal conduction and increases subnormal conduction of premature ventricular beats in the human right ventricle.
Harper et al. (1979) studied this question.
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