Key result
Mexiletine prolonged the VT cycle length from 309 to 361 ms and the block cycle length from 247 to 307 ms (both P<0.001), without significantly changing the effective refractory period.
Why the study?
Does mexiletine administration alter the cycle length of ventricular tachycardia and the effective refractory period in patients with symptomatic VT?
Population
9 consecutive patients with symptomatic ventricular tachycardia (VT)
Comparison
Mexiletine administration vs Baseline (before mexiletine administration)
Design
Case_series
Authors
Loading...
Hypothesis-generating for mexiletine’s conduction effects in VT; too preliminary to guide therapy.
Observational (n=9)
Does mexiletine administration alter the cycle length of ventricular tachycardia and the effective refractory period in patients with symptomatic VT?
Absolute Event Rate: 361% vs 309%
p-value: p=<0.001
Mexiletine prolongs VT cycle length and block cycle length without changing the effective refractory period, indicating its antiarrhythmic mechanism involves depressing intercellular conduction.
Aizawa et al. (1996) conducted an observational in Symptomatic ventricular tachycardia (n=9). Mexiletine vs. Baseline (before mexiletine administration) was evaluated on Ventricular tachycardia cycle length (ms) (p=<0.001). Mexiletine prolonged the VT cycle length from 309 to 361 ms and the block cycle length from 247 to 307 ms (both P<0.001), without significantly changing the effective refractory period.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: