December 1, 1994Pacing and Clinical Electrophysiology

Mexiletine Has No Effect on Defibrillation Energy Requirements in Dogs

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Why the study?

Does mexiletine increase the defibrillation threshold in dogs?

Population

10 mongrel dogs in the open-chest state using general anesthesia

Design

Preclinical

Follow-up

Up to 60 minutes after completion of mexiletine infusion

Authors

SSShigehito SatoHamamatsu University MTMariko H. TsujiKanazawa University HNHiroshi NaitoHiroshima City Asa Citizens Hospital

Discussion

Member takes

Implication

Suggests mexiletine use without DFT concerns in canines; leaves open human applicability.

Structured PICO

Does mexiletine increase the defibrillation threshold in dogs?

Population

10 mongrel dogs in the open-chest state using general anesthesia

Intervention

Mexiletine 1, 2, 4, 6, or 8 mg/kg administered as a loading dose, followed by the same dose/kg per hour

Outcome

Defibrillation threshold (DFT), defined as the minimal energy shock that caused defibrillationsurrogate

Mexiletine does not increase the defibrillation threshold in a canine model, suggesting it may not adversely affect defibrillation energy requirements.

Cite This Study

Sato et al. (1994) studied this question.

synapsesocial.com/papers/6a925db82a0da47949384a36 https://doi.org/10.1111/j.1540-8159.1994.tb02376.x

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Mexiletine Has No Effect on Defibrillation Energy Requirements in Dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mexiletine Has No Effect on Defibrillation Energy Requirements in Dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider