January 15, 1994American Journal of Epidemiology
Predictors of Mortality from Idiopathic Dilated Cardiomyopathy in 356,222 Men Screened for the Multiple Risk Factor Intervention Trial
Population
356,222 men screened for the Multiple Risk Factor Intervention Trial, excluding individuals with a history…
Design
Cohort
Follow-up
average of 12 years
Authors
Discussion
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Implication
Highlights modifiable factors for cardiomyopathy mortality risk stratification in men; extends prior cohort data but remains hypothesis-generating.
Key Points
- To identify clinical and demographic predictors of mortality from idiopathic dilated cardiomyopathy in a large cohort of screened adult men.
- Analyzed 356,222 men screened for the Multiple Risk Factor Intervention Trial (MRFIT), excluding individuals with prior myocardial infarction.
- Tracked vital status through 1986 over an average follow-up of 12 years using state health department death certificates coded by a trained nosologist.
- Calculated age-specific mortality rates and evaluated independent risk factors using proportional hazards regression models to determine adjusted relative risks.
- A total of 206 deaths from idiopathic dilated cardiomyopathy were documented, with age-specific mortality rates rising from 0.10 per 10,000 person-years in men aged 35–39 to 1.16 per 10,000 person-years in men aged 55–57.
- Independent associations with increased mortality were observed for cigarettes smoked per day (p < 0.001), diastolic blood pressure (p < 0.001), and diabetes mellitus (relative risk [RR] = 2.97, p < 0.001).
- Black race was associated with increased risk (RR = 1.59, p = 0.045 unadjusted; RR = 1.58, p = 0.058 income-adjusted), whereas serum cholesterol and income showed no association.
Structured PICO
P
Population
356,222 men screened for the Multiple Risk Factor Intervention Trial, excluding individuals with a history of myocardial infarction.
O
Outcome
Mortality from idiopathic dilated cardiomyopathyhard clinical
Cigarette smoking, higher diastolic blood pressure, and diabetes mellitus are independent predictors of mortality from idiopathic dilated cardiomyopathy in men.
Cite This Study
Coughlin et al. (1994) studied this question.