Why the study?
Does ischemic postconditioning protect against myocardial damage in remodeled myocardium in male Wistar rats?
Population
Male Wistar rats with post-myocardial infarct-remodeled hearts and one kidney one clip hypertensive hearts
Comparison
Ischemic postconditioning induced by six cycles… vs Healthy hearts and/or hearts without ischemic…
Design
Preclinical
Follow-up
90 min of reperfusion
Authors
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Hypothesis-generating in rat remodeled hearts; leaves open clinical translation pending human trials.
Does ischemic postconditioning protect against myocardial damage in remodeled myocardium in male Wistar rats?
Ischemic postconditioning protects remodeled myocardium from ischemia-reperfusion injury primarily through the PI3K-PKB/Akt pathway.
Zhu et al. (2006) studied this question.
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