Population
26 drug-naive subjects with and without symptoms of mild intermittent wheezing, who had never smoked or…
Design
Cross-sectional
Authors
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Should not change beta-agonist prescribing; hypothesis-generating for receptor dysfunction in bronchial hyperresponsiveness.
There is an intrinsic impairment in the function of beta-adrenergic receptors on peripheral mononuclear leukocytes from subjects with high levels of nonspecific bronchial responsiveness, independent of drug therapy.
Connolly et al. (1992) studied this question.
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