June 7, 1974Science
Pineal β-Adrenergic Receptor: Diurnal Variation in Sensitivity
Population
Pineal gland beta-adrenergic receptors (model not explicitly stated in abstract)
Comparison
Light period (0600 to 1800 hours) vs Dark period (1800 to 0600 hours)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May influence rodent melatonin timing; leaves open translation to human circadian or adrenergic therapies.
Structured PICO
P
Population
Pineal gland beta-adrenergic receptors (model not explicitly stated in abstract)
I
Intervention
Light period (0600 to 1800 hours)
C
Comparator
Dark period (1800 to 0600 hours)
O
Outcome
Responsiveness of the pineal beta-adrenergic receptor (serotonin-N-acetyltransferase activity)surrogate
Demonstrates that pineal beta-adrenergic receptor sensitivity exhibits diurnal variation, driven by changes in sympathetic noradrenaline release.
Cite This Study
Romero et al. (1974) studied this question.