October 14, 2013British Journal of PharmacologyOpen Access

The opioid methadone induces a local anaesthetic‐like inhibition of the cardiac N a+channel, N av1.5

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Why the study?

Does methadone inhibit human cardiac Na(v)1.5 channels?

Population

Wild-type and mutant human Na(v)1.5 channels expressed in HEK293 cells

Design

Preclinical

Authors

VSVolker SchulzeeBay (Ireland)CSCarsten StoetzerMedizinische Hochschule Hannover AOAndrias O. O’ReillyLiverpool John Moores University

Discussion

Member takes

Implication

Potential mechanism for methadone cardiotoxicity; leaves open clinical relevance pending human studies.

Structured PICO

Does methadone inhibit human cardiac Na(v)1.5 channels?

Population

Wild-type and mutant human Na(v)1.5 channels expressed in HEK293 cells

Intervention

Methadone (including dextromethadone and levomethadone)

Outcome

Inhibition of Na(v)1.5 channels (tonic and use-dependent block, voltage dependency of inactivation)surrogate

Methadone inhibits cardiac Na(v)1.5 channels via the local anaesthetic-binding site, suggesting a novel molecular mechanism contributing to methadone-induced cardiac arrhythmias.

Cite This Study

Schulze et al. (2013) studied this question.

synapsesocial.com/papers/6a8bd9a160c8c47a9ee3eca1 https://doi.org/10.1111/bph.12465

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Ask AI

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The opioid methadone induces a local anaesthetic‐like inhibition of the cardiac N a+channel, N av1.5

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The opioid methadone induces a local anaesthetic‐like inhibition of the cardiac N a+channel, N av1.5

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider