Why the study?
Does gliadin stimulate a proliferative response in lymphocytes of normal individuals?
Does gliadin stimulate a proliferative response in lymphocytes of normal individuals?
Gliadin can stimulate a proliferative response in lymphocytes from some normal individuals, independent of HLA A or B type.
No clinical implications for gluten-related testing; leaves open HLA-independent gliadin reactivity mechanisms in healthy donors for human validation.
Preparations of gliadin, extracted from wheat gluten, were shown to stimulate a proliferative response by lymphocytes of normal donors. Not all donors responded to gliadin. In all but one case responder or non-responder status remained consistent on retesting. There was no association of ability to respond with HLA A or B type.
No takes yet. Share an insight, caveat, or question.
Frew et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: