Why the study?
Pregnancy confers a high thromboembolic risk in women with inherited antithrombin deficiency; while LMWH is recommended, the use of antithrombin concentrate remains controversial.
Does antithrombin concentrate combined with LMWH prevent thromboembolic complications safely in pregnant women with congenital antithrombin deficiency?
Does antithrombin concentrate combined with LMWH prevent thromboembolic complications safely in pregnant women with congenital antithrombin deficiency?
Antithrombin concentrate combined with LMWH may be a safe and effective strategy to prevent thromboembolic complications in pregnant women with congenital antithrombin deficiency.
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Supports safety consideration in antithrombin-deficient pregnancies; hypothesis-generating and leaves open need for controlled trials.
Bruzzese et al. (2019) studied this question.
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