What question did this study set out to answer?

To assess how recovery of antithrombin activity after antithrombin substitution therapy influences 28-day survival in patients with sepsis-associated disseminated intravascular coagulation.

November 2, 2023Thrombosis JournalOpen Access

The antithrombin activity recovery after substitution therapy is associated with improved 28-day mortality in patients with sepsis-associated disseminated intravascular coagulation

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Authors

TIToshiaki IbaJuntendo University TTTomoki TanigawaJuntendo University HWHideo WadaOsaka Institute of Technology

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Implication

Retrospective analysis reveals higher post-treatment antithrombin activity improves 28-day survival in sepsis-induced DIC, highlighting key prognostic utility.

Key Points

To assess how recovery of antithrombin activity after antithrombin substitution therapy influences 28-day survival in patients with sepsis-associated disseminated intravascular coagulation.
Conducted a retrospective analysis of post-marketing survey records for 1,800 patients with sepsis-associated disseminated intravascular coagulation (DIC) and baseline antithrombin activity ≤ 70% treated with antithrombin concentrates.
Tracked serial changes in antithrombin activity, Sequential Organ Failure Assessment (SOFA) scores, and DIC scores using logistic regression and receiver operating characteristic (ROC) curves to evaluate 28-day survival.
Post-treatment antithrombin activity demonstrated an area under the curve of 0.639 for 28-day mortality, proving superior to both baseline activity and delta change values.
Achieving post-treatment antithrombin activity > 80% was associated with significantly higher estimated 28-day survival compared to levels ≤ 80% (88.2% vs. 74.4%, P < 0.0001).
The survival benefit conferred by post-treatment antithrombin activity was modulated by baseline SOFA scores, age, and whether DIC resolution occurred by Day 6.

Cite This Study

Iba et al. (2023) studied this question.

synapsesocial.com/papers/6a8be276f8241cb45bfb72b4 https://doi.org/10.1186/s12959-023-00556-6

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Implication

Retrospective analysis reveals higher post-treatment antithrombin activity improves 28-day survival in sepsis-induced DIC, highlighting key prognostic utility.

The antithrombin activity recovery after substitution therapy is associated with improved 28-day mortality in patients with sepsis-associated disseminated intravascular coagulation

Discussion

Member takes

Implication

Key Points

Cite This Study

The antithrombin activity recovery after substitution therapy is associated with improved 28-day mortality in patients with sepsis-associated disseminated intravascular coagulation

Discussion

Member takes

Implication

Key Points

Cite This Study

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