Why the study?
Does cardiopulmonary bypass tubing free of diethylhexyl phthalate reduce plasma levels of this plasticizer in patients undergoing coronary artery bypass grafting?
Does cardiopulmonary bypass tubing free of diethylhexyl phthalate reduce plasma levels of this plasticizer in patients undergoing coronary artery bypass grafting?
Using DEHP-free tubing during cardiopulmonary bypass significantly reduces patient exposure to this endocrine-disrupting plasticizer.
DEHP-free tubing reduces plasticizer exposure during CABG; confirms material substitution lowers DEHP burden in randomized cardiac surgery settings.
Di(2-ethylhexyl) phthalate is an excellent plasticizer for polyvinyl chloride but a known endocrine disrupting chemical. To investigate whether tubing containing no diethylhexyl phthalate reduces the overall extraction of this plasticizer during cardiopulmonary bypass, 16 patients undergoing coronary artery bypass grafting were randomly divided into 2 groups of 8 each. Group A had tubing containing diethylhexyl phthalate in the circuit, and group B had no diethylhexyl phthalate in the tubing. The plasma diethylhexyl phthalate level at the end of cardiopulmonary bypass was significantly increased compared to before anesthesia in both groups (group A: 103 +/- 60 to 2,094 +/- 1,046 ng x mL(-1); group B: 135 +/- 60 to 472 +/- 141 ng x mL(-1)), and it was significantly higher in group A than group B. This study demonstrates that using tubing free from diethylhexyl phthalate significantly reduces the release of this agent during cardiopulmonary bypass, which may minimize exposure to diethylhexyl phthalate.
No takes yet. Share an insight, caveat, or question.
Takahashi et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: