Why the study?
Human adenovirus type 7 can cause severe, multisystem disease in children, motivating description of clinical characteristics, management strategies, and outcomes during an outbreak.
What are the clinical characteristics and outcomes of severe human adenovirus type 7 infection in children admitted to a paediatric intensive care unit?
What are the clinical characteristics and outcomes of severe human adenovirus type 7 infection in children admitted to a paediatric intensive care unit?
Severe adenovirus type 7 infection in critically ill children is associated with high rates of multisystem involvement, including myocarditis, and carries a high mortality rate of 57%.
Human adenovirus type 7 (HAdV-7) can cause severe, multisystem disease in children. Between November 2019 and February 2020, 28 children with confirmed HAdV-7 infection were admitted to our paediatric intensive care unit in South India. Most were under 5 years, and 86% required mechanical ventilation. Multisystem involvement included myocarditis (61%), CNS disease (32%), and haemophagocytosis (32%), with a high mortality rate (57%). Follow-up showed recurrent wheeze (33%) and bronchiectasis (16%) in survivors. This case series highlights the clinical characteristics, management strategies and outcome of a large HAdV-7 outbreak in a paediatric intensive care unit. Surveillance is essential to detect and prevent future adenovirus outbreaks in vulnerable paediatric populations.
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Jayakrishnan et al. (2025) studied this question.
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