The effects of dietary linoleate and arachidonate on eicosa-5,8,11-trienoic acid concentration in heart and liver lipids of essential fatty acid-deficient rats were investigated. Pyridoxine deficiency and 4-deoxypyridoxine · HCl addition to the diet were also investigated to reduce the conversion of linoleic into arachidonic acid and thus differentiate the effects produced by both acids. The addition of 4-deoxypyridoxine was observed not to impair the conversion of oleic into eicosa-5,8,11-trienoic acid, but it appeared to reduce slightly the conversion of linoleic into arachidonic acid. Arachidonate was shown to be a specific regulator of eicosa-5,8,11-trienoic acid percentage in heart and liver lipids, whereas linoleate appeared to require its previous conversion into arachidonic acid. Arachidonic acid effect on eicosa-5,8,11-trienoic concentration discards the competence of both synthesis: linoleate into arachidonate and oleate into eicosatrienoate as the possible regulating mechanism.
No takes yet. Share an insight, caveat, or question.
Peluffo et al. (1963) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: