Population
Extensor digitorum longus muscles from dystrophin-deficient mdx and control C57BL/10 mice
Comparison
Repetitive tetanic stimuli in vitro vs Control C57BL/10 mice muscles and muscles at rest
Design
Preclinical
Follow-up
up to 2 hours
Authors
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Does not support increased calcium influx in dystrophin-deficient muscle; challenges hypothesis and leaves open mechanisms in mdx models.
The results do not support the hypothesis that dystrophin deficiency leads to increased calcium influx during contractile activity or increased permeability to cytosolic proteins.
McArdle et al. (1992) studied this question.
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