The protective effect of epigallocatechin gallate (EGCg) on paraquat-induced oxidative stress was determined in rats. Decreases in food intake, body weight gain, and liver triacylglycerol level, which were all caused by being fed a paraquat diet, were mitigated by supplementing EGCg in the paraquat diet. Blood and liver antioxidative enzyme activities were not significantly different among the control, paraquat, and paraquat+EGCg diets-fed rats. The liver thiobarbituric acid reactive substances, however, markedly decreased when the paraquat diet was supplemented with EGCg. These results indicate that EGCg acted in a preventive fashion against paraquat-induced oxidative stress.
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Suzuki et al. (1997) studied this question.
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