400 MHz Two-Dimensional NMR Studies of Cyclodextrin Derivatives for 1H and 13C Chemical Shift Determination

Two-dimensional (2D) NMR spectroscopies, proton (400 MHZ)– proton (400 MHz) and carbon (100 MHz)– proton (400 MHz) chemical shift correlation spectroscopy, were developed as a reliable technique for the strict assignment of crowded and complicated NMR absorptions of substituted cyclodextrin derivatives, pentakis[2,6-O-(t-butyldimethylsilyl)]-A,B-bis-[2-O-(t-butyldimethylsilyl)-6-deoxy-6-(methylthio)]-β-cyclodextrin (2) and A,B-bis[6-deoxy-6-(methylthio)]-β-cyclodextrin (1).