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[reaction: see text] Enantiopure epoxyvinyl sulfones function as templates for the diastereoselective construction of the three stereotetrads of aplyronine A. Lawton S(N)2' addition of 3,5-dimethylpyrazole followed by its displacement in an alcohol-directed Lawton S(N)2' reaction establishes the required product stereochemistry with high selectivity.
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El-Awa et al. (2006) studied this question.
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