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Experimental study demonstrates efficient sp3 C-H alkylation of indoline derivatives with terminal alkenes via a hydroxoiridium catalyst, highlighting a practical route to linear addition products.
Direct alkylation of a secondary sp3 C−H bond of indoline derivatives having a urea moiety with terminal alkenes proceeded in the presence of a hydroxoiridium/1,5‐cyclooctadiene catalyst, which generated an amidoiridium intermediate by reaction with a urea N−H moiety of the indolines, giving the linear addition products in high yields.
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Nakamura et al. (2018) studied this question.
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