The Rh(III)-catalyzed C7-alkylation of indolines with nitroalkenes under an ambient atmosphere is disclosed, affording diverse 7-(2-nitroalkyl)indolines with excellent chemo- and regioselectivity. The directing group is readily removable, and the resulting products can be oxidized to deliver 7-(2-nitroalkyl)indoles. Moreover, a plausible mechanism is proposed on the basis of control experiments.
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Liu et al. (2026) studied this question.
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