Why the study?
Is the -36A>C phospholamban gene polymorphism associated with heart failure or worse prognosis in patients with HF?
Population
881 patients with heart failure and 1,259 individuals from the general population in Brazil
Comparison
Presence of the -36A>C alteration in the… vs Absence of the -36A>C alteration / general…
Design
Cohort
Authors
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No support for PLN -36A>C testing in HF risk assessment; leaves open ancestry-specific genetic effects in broader populations.
Is the -36A>C phospholamban gene polymorphism associated with heart failure or worse prognosis in patients with HF?
The -36A>C phospholamban gene polymorphism is not associated with heart failure susceptibility or worse prognosis in a Brazilian population.
Santos et al. (2009) studied this question.
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