What question did this study set out to answer?

To investigate whether immunoglobulins from patients with myxedematous endemic cretinism inhibit thyroid-stimulating hormone (TSH)-induced thyroid cell growth in vitro.

January 1, 1991Autoimmunity

Thyroid Atrophy in Myxedematous Endemic Cretinism: Possible Role for Growith-Blocking Immunoglobulins

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Authors

KTKumiko TsuboiToho University NLN. LimaUniversidade do Estado do Rio de Janeiro SISidney H. IngbarDartmouth College

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Implication

Laboratory study reveals inhibition of TSH-stimulated thyroid cell growth by immunoglobulins in endemic cretins, suggesting an autoimmune mechanism for thyroid atrophy.

Key Points

To investigate whether immunoglobulins from patients with myxedematous endemic cretinism inhibit thyroid-stimulating hormone (TSH)-induced thyroid cell growth in vitro.
Purified immunoglobulin G (IgG; 2 mg) from 8 patients with endemic cretinism, of whom 6 presented with clinical/biochemical hypothyroidism and 2 had borderline low T4 with exaggerated TSH response to TRH.
Assayed cell growth inhibition in cultured, TSH-stimulated FRTL-5 rat thyroid cells by quantifying the incorporation of [3H]-thymidine into DNA.
IgG from 6 of 8 patients inhibited TSH-induced FRTL-5 cell growth, with DNA incorporation of [3H]-thymidine reduced by 26% to 87%.
Seven patients exhibited clinical thyroid atrophy or minimal enlargement despite chronic iodine deficiency, whereas IgG from the single patient with a large multinodular goiter showed no growth-inhibitory activity.
The percentage of thyroid growth inhibition was directly correlated with basal serum TSH concentration.

Cite This Study

Tsuboi et al. (1991) studied this question.

synapsesocial.com/papers/6a8bf48e60c8c47a9ee3f5ed https://doi.org/10.3109/08916939109007645

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Implication

Laboratory study reveals inhibition of TSH-stimulated thyroid cell growth by immunoglobulins in endemic cretins, suggesting an autoimmune mechanism for thyroid atrophy.

Thyroid Atrophy in Myxedematous Endemic Cretinism: Possible Role for Growith-Blocking Immunoglobulins

Discussion

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Implication

Key Points

Cite This Study

Thyroid Atrophy in Myxedematous Endemic Cretinism: Possible Role for Growith-Blocking Immunoglobulins

Discussion

Member takes

Implication

Key Points

Cite This Study

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