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Five alkylating agents and x-rays, administered to pregnant rats on the twelfth day of gestation and which were killed on the twenty-first day, produced malformations in the fetuses. The dosages producing four measured effects on the pregnant rats and their fetuses for each of the five alkylating agents and x-rays were found to resemble each other more than in a comparison of six antimetabolites in a previous study. There is a similarity of the malformations produced by these agents, but some distinct differences in gross soft-tissue and skeletal abnormalities are described.
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M. Lois Murphy (1959) studied this question.
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