Kanamycin 6''-Acetate and Ribostamycin 6''-Acetate, Enzymatically Inactivated Products by Pseudomonas Aeruginosa

As reported in a previous paper,1} 3'94rdideoxykanamycin B is converted to its 6;acetate by an enzymatic reaction with ATP, coenzyme A, acetate and an enzyme solution prepared from Pseudomonasaeruginosa GN 315. In this communication, we report the inactivation of kanamycin and ribostamycin (SF-733)2) by the same enzyme solution of P. aeruginosa GN315, producing kanamycin 6'-acetate and ribostamycin 67-acetate.