Population
Human myotubes isolated from patients harboring native RYR1 I4898T and R4893W mutations linked to central…
Comparison
Activation of the ryanodine receptor via surface… vs Myotubes from control individuals or malignant…
Design
Preclinical
Authors
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IL-6 elevation in CCD myotubes may link RYR1 dysfunction to muscle pathology; hypothesis-generating for inflammatory targets in RYR1 myopathies.
Abnormal release of calcium via mutated RYR enhances the production of the inflammatory cytokine IL-6, which may affect signaling pathways responsible for the trophic status of muscle fibers.
Ducreux et al. (2004) studied this question.
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