December 22, 2022Pflügers Archiv - European Journal of PhysiologyOpen Access

Impact of the glutamatergic neurotransmission within the A5 region on the cardiorespiratory response evoked from the midbrain dlPAG

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Why the study?

To characterize the role of glutamate within the functional interaction between the dorsolateral periaqueductal grey matter and the pontine A5 region.

Population

Spontaneously breathing anaesthetized rats

Comparison

dlPAG electrical stimulation before vs after A5 microinjection of kynurenic acid, DAP-5, CNQX, or MCPG

Design

Preclinical animal experiment

Authors

MGMarta González-GarcíaUniversity of Michigan LCLaura Carrillo-FrancoInstituto de Investigación Biomédica de Málaga CPCarlos Antonio Peinado-AragonésUniversidad de Málaga

Discussion

Member takes

Implication

May modulate PAG-evoked cardiorespiratory responses via A5 glutamate in rats; leaves open translation to human physiology or therapy.

Structured PICO

Population

Spontaneously breathing anaesthetized rats (sodium pentobarbitone 60 mg/kg i.p., supplemented with 20 mg/kg i.p.)

Intervention

Microinjection within the A5 region of either kynurenic acid (5-10 nmol), DAP-5 (1 pmol), CNQX (1 pmol) or MCPG (0.1 nmol) during electrical stimulation of the dlPAG

Comparator

Electrical stimulation of the dlPAG before microinjection

Outcome

Cardiorespiratory response (tachypnoea, tachycardia, and pressor response)surrogate

Glutamate neurotransmission in the A5 region modulates the cardiorespiratory response evoked by dlPAG stimulation in rats.

Cite This Study

González-García et al. (2022) studied this question.

synapsesocial.com/papers/6a8bf7021692ae2bc0f4773c https://doi.org/10.1007/s00424-022-02777-6

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Impact of the glutamatergic neurotransmission within the A5 region on the cardiorespiratory response evoked from the midbrain dlPAG

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Impact of the glutamatergic neurotransmission within the A5 region on the cardiorespiratory response evoked from the midbrain dlPAG

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider