Why the study?
How many molecules of anti-poliovirus antibody are required for prophylaxis and therapy of poliomyelitis?
Population
Monkeys (experimental disease) and theoretical calculations for epidemic conditions
Design
Preclinical
Authors
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Animal data suggest low antibody thresholds may protect against polio; hypothesis-generating for human prophylaxis and therapy.
How many molecules of anti-poliovirus antibody are required for prophylaxis and therapy of poliomyelitis?
Theoretical calculations suggest a very low concentration of anti-poliovirus antibodies may be sufficient for prophylaxis.
K. M. Stevens (1959) studied this question.
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