What is the clinical evidence from this study?

Study design: Other. Population: Poliovirus infection. Intervention: Specific antiserum vs. Corresponding controls. Primary outcome: Mortality.

What question did this study set out to answer?

To evaluate the mode of poliovirus dissemination within the central nervous system and determine whether post-inoculation intravenous antiserum can reduce mortality and paralysis.

February 1, 1958The Journal of Immunology

A Study of the Effect of Antiserum on Poliovirus Infection Induced by the Intraspinal Inoculation of Rhesus Monkeys

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Key result

Intravenous administration of specific antiserum in rhesus monkeys infected with poliovirus reduced mortality from 75-100% down to 0%.

Authors

OLOscar C. LiuUniversity-National Oceanographic Laboratory System JCJoseph E. CarterMerck & Co., Inc., Rahway, NJ, USA (United States)ADArmand N. DeSanctisIfremer

Discussion

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Implication

Supports antiserum development for viral infections; leaves open translation to human poliomyelitis.

Key Points

To evaluate the mode of poliovirus dissemination within the central nervous system and determine whether post-inoculation intravenous antiserum can reduce mortality and paralysis.
Inoculated rhesus monkeys intraspinally with the Mahoney strain of poliovirus and examined central nervous system tissue at multiple timepoints using TCID50 titrations and histology.
Administered intravenous specific antiserum immediately, 24 hours, or 48 hours post-infection, and assessed clinical outcomes alongside untreated control monkeys.
Tissue analysis revealed that poliovirus spreads through cell-to-cell contact across anatomically contiguous gray matter in the central nervous system rather than along nerve fibers.
Intravenous antiserum administered immediately or within 24 to 48 hours reduced mortality from 75–100% in control animals to 0% in treated animals.
Antiserum significantly reduced the extent of skeletal muscle paralysis compared to controls, though delays in treatment administration led to broader muscular involvement.

PICO

Population

Rhesus monkeys infected with the Mahoney strain of poliovirus via intraspinal inoculation.

Intervention / Comparator

Specific antiserum vs Corresponding controls

Primary Outcome

Mortality

Cite This Study

Liu et al. (1958) studied Poliovirus infection. Specific antiserum vs. Corresponding controls was evaluated on Mortality. Intravenous administration of specific antiserum in rhesus monkeys infected with poliovirus reduced mortality from 75-100% down to 0%.

synapsesocial.com/papers/6a9c9adde4895faeb35d31fd https://doi.org/10.4049/jimmunol.80.2.106

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A Study of the Effect of Antiserum on Poliovirus Infection Induced by the Intraspinal Inoculation of Rhesus Monkeys

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

A Study of the Effect of Antiserum on Poliovirus Infection Induced by the Intraspinal Inoculation of Rhesus Monkeys

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

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Also Consider