Key result
In Rhesus monkeys vaccinated with Lansing poliomyelitis virus, the minimal level of serum antibody associated with complete immunity to intracerebral challenge was 3.0 (1/1000 dilution).
Why the study?
What is the minimal level of serum antibody associated with intracerebral immunity in Rhesus monkeys vaccinated with Lansing poliomyelitis virus?
Population
79 Rhesus monkeys
Design
Preclinical
Authors
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Provides benchmark for protective titers in primate polio models; leaves open translation to human vaccine efficacy thresholds.
What is the minimal level of serum antibody associated with intracerebral immunity in Rhesus monkeys vaccinated with Lansing poliomyelitis virus?
A serum antibody titer of 3.0 (1/1000 dilution) is the minimal level associated with complete intracerebral immunity to Lansing poliomyelitis virus in vaccinated Rhesus monkeys.
Isabel M. Morgan (1949) studied Poliomyelitis (n=79). Active Lansing poliomyelitis virus vaccine was evaluated on Immunity to intracerebral injection of 10,000 PD50 of active virus. In Rhesus monkeys vaccinated with Lansing poliomyelitis virus, the minimal level of serum antibody associated with complete immunity to intracerebral challenge was 3.0 (1/1000 dilution).
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