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October 1, 1950PEDIATRICS

Poliomyelitis

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Population

Cases of poliomyelitis admitted to Children's Hospital, San Francisco, during a six year period.

Design

Case_series

Authors

HTH.E. ThelanderUniversity of MinnesotaMSMaxine M. SehringUCSF Benioff Children's HospitalESEdward B. ShawSan Francisco General Hospital

Discussion

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Implication

Does not support clinical use of pooled irradiated plasma in poliomyelitis; leaves open any therapeutic role amid highly variable outcomes.

Key Points

  • To analyze clinical characteristics, disease course, and factors affecting outcomes among hospitalized poliomyelitis cases, focusing on triggers of paralytic progression.
  • Retrospective review of poliomyelitis admissions over a 6-year period at Children's Hospital in San Francisco.
  • Evaluation of clinical features including unrelated systemic infections, traumatic precipitating factors, biphasic fever trajectories, and treatment with pooled irradiated human plasma.
  • Unrelated systemic infections may serve as critical precipitating traumatic factors comparable to physical trauma, elevating central nervous system susceptibility and converting latent infections into active paralytic disease.
  • Rigorous diagnostic verification reveals that true nonparalytic cases are rare, as subtle or minimal paralysis commonly develops and resolves before the conclusion of hospitalization.
  • Pooled irradiated human plasma showed modest qualitative therapeutic benefits in shifting overall clinical outcomes, though wide clinical variability precluded statistical confirmation.

Structured PICO

P
Population
Cases of poliomyelitis admitted to Children's Hospital, San Francisco, during a six year period (modified by age, economic status, higher proportion of females, and more severe cases).
I
Intervention
Pooled irradiated human plasma
O
Outcome
Paralytic or nonparalytic outcome

An analysis of poliomyelitis cases suggests that systemic infections may precipitate paralytic disease and that pooled irradiated human plasma may have limited therapeutic value.

Limitations

  • Admissions were modified by age, economic status, higher proportion of females, and more severe cases referred from outlying districts.

Cite This Study

Thelander et al. (1950) studied this question.

synapsesocial.com/papers/6a8bfa5452e1a91077e988c8https://doi.org/10.1542/peds.6.4.581
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FOLLOW-UP STUDY IN SEVENTY-FIVE CASES OF NONPARALYTIC POLIOMYELITIS1953 · 6 citations
  2. 2An Etiologic Study of Clinical Paralytic Poliomyelitis1961 · 20 citations
  3. 3ACUTE POLIOMYELITIS IN INFANTS UNDER ONE YEAR OF AGE: EPIDEMIOLOGICAL AND CLINICAL FEATURES1955 · 16 citations
  4. 4Unexplained Coma in a Toddler2009
  5. 5Poliomyelitis in Children1960 · 10 citations