Myocardial oxidative stress correlates with left ventricular dysfunction on strain echocardiography in a rodent model of sepsis

Murine model of sepsis including C57BL/6J mice (control n=10, sham n=25, cecal ligation and puncture [CLP] n=33) and mitochondrial catalase-upregulated C57BL/6J MCAT+/+ mice (n=12) with wild-type (WT) animals for comparison.

Cecal ligation and puncture (CLP) to induce sepsis, and genetic upregulation of mitochondrial catalase (MCAT+/+).

Control mice, sham-operated mice, and wild-type (WT) mice.

Myocardial function assessed by longitudinal strain on echocardiography and cardiomyocyte oxidative stress.surrogate