Key result
Increased CIMT is linked to ~8-fold more frequent abnormal myocardial perfusion in asymptomatic diabetes.
Why the study?
Identification of asymptomatic patients with type 2 diabetes at increased risk for coronary artery disease remains a challenge.
Does increased carotid intima-media thickness predict abnormal myocardial perfusion in asymptomatic patients with type 2 diabetes?
Observational (n=98)
Does increased carotid intima-media thickness predict abnormal myocardial perfusion in asymptomatic patients with type 2 diabetes?
Absolute Event Rate: 75% vs 9%
p-value: p=<0.001
Increased carotid intima-media thickness is strongly associated with abnormal myocardial perfusion in asymptomatic patients with type 2 diabetes, suggesting its utility for CAD risk stratification.
OBJECTIVE Identification of asymptomatic patients with type 2 diabetes at increased risk for coronary artery disease (CAD) remains a challenge. We evaluated the potential of carotid intima-media thickness (CIMT) for prediction of abnormal myocardial perfusion in this population. RESEARCH DESIGN AND METHODS CIMT and SPECT myocardial perfusion imaging were assessed in 98 asymptomatic patients with type 2 diabetes. An increased CIMT was defined as ≥75th percentile of reference values. RESULTS Increased CIMT was an independent predictor of the extent of abnormal perfusion (P < 0.001). In patients with increased CIMT as compared with patients with normal CIMT, abnormal perfusion (75 vs. 9%) and severely abnormal perfusion (28 vs. 3%) were observed more frequently. CONCLUSIONS Increased CIMT was significantly related to the presence and extent of abnormal myocardial perfusion. Assessment of CIMT may be useful to identify asymptomatic patients with type 2 diabetes at higher risk for CAD.
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Djaberi et al. (2009) conducted an observational in Type 2 diabetes (n=98). Increased carotid intima-media thickness (CIMT ≥75th percentile) vs. Normal CIMT (<75th percentile) was evaluated on Abnormal myocardial perfusion (p=<0.001). Increased CIMT (≥75th percentile) in asymptomatic type 2 diabetes was associated with more frequent abnormal myocardial perfusion compared to normal CIMT (75% vs. 9%, P<0.001).
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