Why the study?
Does losartan prevent changes in heart rate variability and plasma corticosterone levels in rats subjected to immobilization stress?
Does losartan prevent changes in heart rate variability and plasma corticosterone levels in rats subjected to immobilization stress?
In a rat model, losartan prevents stress-induced increases in corticosterone but not reductions in heart rate variability, suggesting complex renin-angiotensin system involvement in stress responses.
Attenuates corticosterone but not HRV changes in stressed rats; leaves open differential RAS effects on HPA versus autonomic pathways in humans.
In this study, the effects of losartan, an angiotensin II receptor antagonist, on heart rate variability and the changes of plasma corticosterone levels caused by immobilization stress were investigated. Losartan (3 mg/kg, p.o.) significantly prevented increases in plasma corticosterone levels in both losartan+acute stress and losartan+chronic stress groups. But, losartan did not prevent the diminution of the power of heart rate variability caused by stress. Our results supported the idea that the renin-angiotensin system is also involved in the stress- induced cardiovascular response, besides the autonomic nervous system. But, the effects of losartan on heart rate variability remained controversial.
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Üresin et al. (2004) studied this question.
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