Why the study?
Is tiagabine safe and well-tolerated as an add-on therapy in patients with difficult-to-control epilepsy?
Population
Approximately 1,000 patients with epilepsy with difficult-to-control seizures on existing antiepileptic drugs
Comparison
Tiagabine hydrochloride as add-on therapy vs Placebo
Design
Meta-analysis, double-blind
Authors
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Higher AE discontinuations warrant monitoring and counseling; reinforces meta-analytic evidence for acceptable add-on tolerability in refractory epilepsy.
Is tiagabine safe and well-tolerated as an add-on therapy in patients with difficult-to-control epilepsy?
Tiagabine appears generally well-tolerated as an add-on therapy for difficult-to-control epilepsy, with mostly mild to moderate and transient adverse events.
Ilo E. Leppik (1995) studied this question.
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