Prognostic Significance of Signs of Life in Out-of-Hospital Cardiac Arrest Patients Undergoing Extracorporeal Cardiopulmonary Resuscitation*

Naofumi Bunya; Hirofumi Ohnishi; Takehiko Kasai; Yoichi Katayama; Ryuichiro Kakizaki; Satoshi Nara; Shinichi Ijuin; Akihiko Inoue; Toru Hifumi; Tetsuya Sakamoto; Yasuhiro Kuroda; Eichi Narimatsu

doi:10.1097/ccm.0000000000006116

November 3, 2023Critical Care Medicine

Prognostic Significance of Signs of Life in Out-of-Hospital Cardiac Arrest Patients Undergoing Extracorporeal Cardiopulmonary Resuscitation*

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Key Points

To determine whether the presence of signs of life on hospital arrival is independently associated with favorable neurologic outcomes in out-of-hospital cardiac arrest patients treated with extracorporeal cardiopulmonary resuscitation.
Retrospective multicenter registry study analyzing 1,395 adult patients who received extracorporeal cardiopulmonary resuscitation across 36 Japanese medical centers in the SAVE-J II database between 2013 and 2018.
Patients were classified based on signs of life upon hospital arrival (gasping, pupillary light reflex, or body movement), with the primary endpoint defined as favorable neurologic outcome (Cerebral Performance Category 1 or 2) at discharge.
Signs of life on arrival were observed in 17.9% of patients (250/1395) and yielded a significantly higher rate of favorable neurologic outcomes compared to those without signs of life (38.0% vs. 8.1%; p < 0.001).
Multivariate regression demonstrated that signs of life on arrival independently predicted favorable neurologic recovery (odds ratio, 5.65; 95% CI, 3.97–8.03; p < 0.001).

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Implication

Multicenter registry study shows signs of life improve neurologic outcomes in cardiac arrest patients undergoing ECPR, suggesting critical prognostic utility for resuscitation decisions.

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Bunya et al. (2023) studied this question.

synapsesocial.com/papers/6a8c0041d5d4290f64f49471 https://doi.org/10.1097/ccm.0000000000006116

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Prognostic Significance of Signs of Life in Out-of-Hospital Cardiac Arrest Patients Undergoing Extracorporeal Cardiopulmonary Resuscitation*

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

Prognostic Significance of Signs of Life in Out-of-Hospital Cardiac Arrest Patients Undergoing Extracorporeal Cardiopulmonary Resuscitation*

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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