What does this research mean for the field?

Extensively drug-resistant clinical Pseudomonas aeruginosa isolates in India possess extensive antimicrobial resistance and virulence gene repertoires, including the emergence of high-risk sequence types ST3043 and ST1047 reported for the first time in the region. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Investigate antimicrobial resistance determinants and virulence profiles among extensively drug-resistant clinical Pseudomonas aeruginosa isolates using whole-genome sequencing.

August 24, 2026Microbial Drug Resistance

High-Risk Clones of Carbapenem-Resistant Pseudomonas aeruginosa in India: Genome and Traits

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Authors

SSSeshan SivasankarPSG Institute of Medical Sciences & Research MGMartin Peter GrobuschAlbert Schweitzer Hospital LSLavanya SriramajayamPSG Institute of Medical Sciences & Research

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Implication

Genomic surveillance study reveals diverse antimicrobial resistance and virulence genes across high-risk Pseudomonas aeruginosa isolates, highlighting the emergence of novel sequence types.

Key Points

Investigate antimicrobial resistance determinants and virulence profiles among extensively drug-resistant clinical Pseudomonas aeruginosa isolates using whole-genome sequencing.
Analyzed five extensively drug-resistant P. aeruginosa clinical isolates collected from bile, broncho-alveolar lavage, and wound swabs.
Characterized carbapenemase production and genotype using the modified Hodge test, conventional PCR, and whole-genome sequencing.
All isolates exhibited resistance to >50% of tested antibiotics and carried multiple resistance genes, including blaNDM-1, blaVIM variants, blaOXA variants, and blaPDC variants.
Genomic profiling revealed extensive virulence determinants involved in biofilm formation, alginate synthesis, quorum sensing, and exotoxins alongside multidrug efflux pumps.
Sequence typing identified ST357 (n=2) and ST773, while reporting ST1047 and ST3043 for the first time in India.

Cite This Study

Sivasankar et al. (2026) studied this question.

synapsesocial.com/papers/6a8c009fbca056c88e6df6be https://doi.org/10.1177/10766294261480779

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Implication

Genomic surveillance study reveals diverse antimicrobial resistance and virulence genes across high-risk Pseudomonas aeruginosa isolates, highlighting the emergence of novel sequence types.

High-Risk Clones of Carbapenem-Resistant Pseudomonas aeruginosa in India: Genome and Traits

Discussion

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Implication

Key Points

Cite This Study

High-Risk Clones of Carbapenem-Resistant Pseudomonas aeruginosa in India: Genome and Traits

Discussion

Member takes

Implication

Key Points

Cite This Study

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