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It appears that no two malignant tumours are alike. Their uniqueness could be guessed from histological and cytological appearances, but we now have data about their chromosomes. A brief review of the literature makes it clear that the common kinds of carcinoma in man show abnormalities of the karyotype which are different in every case. Illustrations are given from three unpublished cases, two of primary carcinoma and one of carcinoma-in-situ adjacent to an area of early invasion. It is concluded that the types of tumours studied are the product of cellular selection from populations of cells with karyotypic variation.
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A. I. Spriggs (1964) studied this question.
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