Why the study?
To update the 2014 USPSTF recommendation on the effectiveness of low-dose aspirin to prevent preeclampsia, a condition contributing substantially to maternal and infant morbidity and mortality.
Does daily low-dose aspirin prevent preeclampsia and related morbidity and mortality in pregnant persons at high risk for preeclampsia?
Population
Pregnant persons at high risk for preeclampsia with no prior adverse effects or contraindications to low-dose aspirin
Comparison
Low-dose aspirin (81 mg/d) after 12 weeks of gestation vs not specified
Design
USPSTF recommendation based on a systematic review
Authors
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Supports aspirin initiation after 12 weeks in high-risk pregnancies; confirms moderate-certainty net benefit for preeclampsia prevention.
Does daily low-dose aspirin prevent preeclampsia and related morbidity and mortality in pregnant persons at high risk for preeclampsia?
The USPSTF recommends daily low-dose aspirin (81 mg/d) starting after 12 weeks of gestation to prevent preeclampsia in high-risk pregnant persons.
Davidson et al. (2021) studied this question.