Intracranial arterial spasm in the dog

✓ A chronic canine model for the investigation of intracranial arterial spasm was designed and used to study spasm produced by rapid and slow cisternal injections of fresh or heparinized autogenous whole blood, or serum from incubated autogenous blood. Spasm so produced begins within 10 minutes after the injection and lasts from several hours to days. It affects primarily the major arteries of the circle of Willis, especially the proximal anterior cerebral arteries, and it does not seem to involve the extradural arterial tree.