Why the study?
Does transgenic overexpression of IGF-1 prevent age-related decreases in specific force and intracellular Ca2+ in skeletal muscle fibers of mice?
Population
Single intact muscle fibres from the flexor digitorum brevis muscle of young and old transgenic and…
Comparison
Sustained transgenic overexpression of… vs Wild-type mice (young and old)
Design
Preclinical
Authors
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Supports IGF-1 overexpression in preclinical muscle aging models; leaves open translation to human sarcopenia therapies.
Does transgenic overexpression of IGF-1 prevent age-related decreases in specific force and intracellular Ca2+ in skeletal muscle fibers of mice?
Transgenic overexpression of IGF-1 in skeletal muscle prevents age-related decline in peak intracellular Ca2+ and specific force in mice.
Messi et al. (2003) studied this question.
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